B3CARE

Research Collaboration

About

Lung cancer, chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), the so-called Big-3 (B3), are expected to cause most deaths by 2050. Early detection and prevention are crucial to lower the disease burden. Innovative low-dose computed tomography (CT) allows simultaneous, integrated assessment of early imaging biomarkers of lung cancer, COPD and CVD. Major advantages of integrated B3 screening are expected due to shared risk factors, B3 interdependence and health economic yield comparison to single disease screening. However, a major impediment before establishing a B3 screening program is the lack of validated and standardized B3 imaging biomarkers. The aim of this project is to advance the technology readiness level (TRL) of integrated B3 screening with at least 2 levels. To reach this objective, B3CARE will develop a large, high-quality imaging data biobank to provide biomarker reference values and validate B3 biomarkers using novel image analysis software and novel machine learning approaches. This will accelerate software development for CT-imaging data post-processing. Also, the expected substantial health economics potential of combined B3 imaging biomarkers for personalized health strategies is evaluated. B3CARE will thus provide an invaluable resource for the accelerated development and implementation of B3 imaging biomarkers and computer aided decision support.

Projects

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WP1 Data Acquisition and Merging

Consolidate, tag and archive data.

WP2 Reference values for B3 imaging biomarkers.

Obtain reference values from the general population.

WP3 B3 image biomarker software validation.

Approach technology readiness.

WP4 Machine Learning

Use ML for biomarkers.

WP5 Training and education.

Prepare professionals.

WP7 General Education

Information for all

Our Team

Academics

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Rozemarijn Vliegenthart

Professor of Radiology

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Christoph Brune

Associate Professor Intelligent Imaging

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Cornelis H. Slump

Professor of Medical Imaging

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Ferdinand van der Heijden

Associate Professor Electrical Engineering

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Erik Koffijberg

Associate Professor of Health Economics

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Luuk J. Spreeuwers

Assistant Professor Electrical Engineering

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Maarten J. Ijzerman

Professor of Health Technology

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Matthijs Oudkerk

Professor of Radiology

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Pim van der Harst

Scientific Director Cardiac Catheterization Laboratory

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Peter van Ooijen

Coordinator Machine Learning Lab

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Marleen de Bruijne

Professor of Medical Image Analysis

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Raymond N. J. Veldhuis

Professor of Biometric Pattern Recognition

PhD Students

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Carina Behr

PhD Candidate

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Elfi Hofmeijer

PhD Candidate

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Ivan Dudurych

PhD Candidate

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Lu Liu

PhD Candidate

Administration

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Elwin Buisman

Center for Information Technology

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Hans Brouwers

Center for Information Technology

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Nick Arends

Project Manager

Recent Publications

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B3Care Background

Lung cancer, chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD), the so-called Big-3 (B3), are expected to …

Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study

Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. …

Contact

  • Hanzeplein 1, Groningen, NL-GR, 9713GZ, Netherlands
  • Make your way to Triadegebouw and go to the second floor, corridor G2.
  • Mon-Fri 09:00 to 17:00