Lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease, the so-called Big-3 (B3), are responsible for high rates of morbidity and mortality. B3CARE is a research collaboration project, with a final ambition to establish an integrated B3 computed tomography (CT) screening program and accelerate software development for CT imaging data post-processing. A large-scale, high-quality imaging data biobank is established containing data from different projects all stored in the XNAT opensource platform. The data can be accessed via the Virtual Research Workspace, a two-way verification secured collaboration environment for conducting data analyses jointly and securely.